Based on available data, including approximately 20 studies using animal models, human observations, temporal correlations and pharmacological/toxicological considerations, it has been concluded, beyond reasonable doubt and without evidence to the contrary, that exposure of infants and children to paracetamol causes many, if not most cases of autism spectrum disorder (ASD). Affected children are referred to as autistic or autistic. Due to the restrictions, many of them need help and support - sometimes for life. Autism is often accompanied by impairments in language development and disorders of intelligence development. However, the relative number of cases of autism spectrum disorder that could be triggered by paracetamol has not yet been estimated. In this study, authors Parker and colleagues examined a range of evidence, including acetaminophen-induced reductions in social awareness in adults, the prevalence of autism spectrum disorders over time, and rough estimates of the relative numbers of autism spectrum disorders -Cases triggered by paracetamol in different phases of neurodevelopment. They conclude that the very early postnatal period poses the greatest risk for acetaminophen-induced autism spectrum disorders, and that the near-ubiquitous use of acetaminophen during early development may account for the emergence of the vast majority, possibly 90 % or more of all cases of autism spectrum disorder could be responsible. Although evidence that acetaminophen is harmful to neurological development has been accumulating for more than a decade, numerous studies show that acetaminophen is often given to children in amounts greater than currently approved and under conditions where it provides no benefit. In addition, studies have failed to demonstrate long-term benefits of acetaminophen in the pediatric population, so there is no valid rationale for continued use of the drug in this population given the risks to neurodevelopment.

Parker W, Anderson LG, Jones JP, Anderson R, Williamson L, Bono-Lunn D, Konsoula Z. The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits. Children (Basel). 2023 Dec 29;11(1):44. doi: 10.3390/children11010044. PMID: 38255358; PMCID: PMC10814214.