Rapid blood flow and changes in brain activity as the cause

Coffee is the most socially accepted drug
Kiel (pte/05.05.2009/06:10) – Caffeine stimulates the body, but can also be addictive and causes headaches and fatigue when the usual daily dose is missed. Psychiatrists from the University of Vermont College of Medicine in the scientific journal Psychopharmacology. They investigated which physical processes are triggered by a sudden cessation of caffeine intake. Test subjects who had taken caffeine capsules over a longer period showed clear reactions after stopping intake, similar to the typical withdrawal symptoms of addictive substances. The speed of blood flow in the brain and also the theta rhythms in the EEG increased, which the researchers see as the main causes of the headaches. The subjects also reported feeling particularly tired, exhausted, listless, or lethargic during withdrawal.

“Caffeine constricts blood vessels, which leads to faster blood flow and, in the short term, also to high blood pressure. At the same time, the oxygen supply to the cells increases,” explains Hartmut Göbel, head of the Kiel Pain Clinic , in a pressetext interview. The active ingredient, found in coffee, tea, cola, energy drinks, and also cocoa, targets the receptors that otherwise signal the cell to rest, thus preventing fatigue. “The problem is that the brain notices a constant dose of caffeine and becomes accustomed to it. Therefore, the more caffeine you consume, the less effective it becomes,” says Göbel. If you deprive the body of caffeine after this habituation, it can lead to headaches, nausea, fatigue, and depression. “This was clearly demonstrated by the finding that most people have headaches on Saturdays because they don't consume their usual dose of coffee on the weekend.”

Medically and pharmacologically, caffeine is a drug, Göbel emphasizes. However, the addiction that develops with regular consumption is so well-organized in society that it's hardly noticeable. "Coffee is part of everyday life and is consumed constantly. It's always available at work or at events, or people simply take a coffee break." Opportunities for coffee consumption also exist in all urban shopping areas, while in England, the traditional tea time at five o'clock in the afternoon serves the same function: to counteract the usual fatigue at that time of day. "Strongly brewed tea contains the same concentration of caffeine as coffee," the pain specialist explains.

Because caffeine's stimulating effect temporarily relieves headaches, it has long been used as a medicine. "Coca-Cola was originally developed as a therapy for headaches," says Göbel. However, the pain specialist criticizes the use of the stimulant in medications. "This is the case, for example, with the most common analgesics for headaches. These combination drugs combine painkillers with caffeine, which carries the risk of addiction. There are patients who regularly take 30 painkillers a day for this reason." Instead of combinations, monotherapy, which uses only one active ingredient and omits caffeine, is more sensible, the pain specialist emphasizes. Coffee can then be consumed independently of the painkiller if the caffeine effect is desired.

According to Göbel, coffee, when consumed in moderation, is a socially acceptable drug because it enhances performance. Furthermore, there is no medical reason to avoid up to four cups of coffee per day. "Depending on the strength, a cup contains between 30 and 100 milligrams of caffeine. However, caffeine is harmless up to a dose of 200 milligrams." Those who enjoy drinking a lot of coffee should prepare it as weakly as possible, recommends the Kiel-based physician. "However, it is important to give body and mind sufficient balance."

Caffeine tricks brain cells into thinking they are active and have energy

Caffeine tricks brain cells into thinking they are active and have energy

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Caffeine and Headache

Overview of the study