Symmetrical drug-induced intertriginous and flexural exanthem (SDRIFE or baboon syndrome) in migraine therapy

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), formerly also called baboon syndrome, is characterized by a symmetrical rash accompanied by skin reddening with typical localization in the area of ​​the buttocks, genitals and joint flexures.

Monoclonal CGRP antibodies (CGRP mAbs) are a new class of drugs for the prevention of migraine.

We present the first case of SDRIFE that occurred in temporal association with the use of erenumab for migraine prevention.

Given the widespread prevalence of migraine, knowledge of this unusual, rare dermatological syndrome is important.

It is crucial to recognize the connection between the drug and the localized exanthem, which can occur far from the injection site.

Carl H. Göbel, Axel Heinze, Sarah Karstedt, Anna Cirkel, Thomas F. Münte & Hartmut Göbel: First Report of Symmetrical Drug-related Intertriginous and Flexural Exanthema (SDRIFE or Baboon Syndrome) After Erenumab Application for Migraine Prevention. Pain Ther (2022). https://doi.org/10.1007/s40122-022-00417-6

Link to the original publication:

https://link.springer.com/article/10.1007/s40122-022-00417-6