Symmetric drug-related intertriginous and flexural rash (SDRIFE or Baboon syndrome) in migraine therapy

The symmetrical drug-related intertriginous and flexural rash (SDRIFE), previously also known as baboon syndrome, is characterized by a symmetrical rash accompanied by redness of the skin and is typically localized in the buttocks, genitals and of the joint bends.

CGRP monoclonal antibodies (CGRP mAbs) are a new class of medications used to prevent migraines.

We present the first case of SDRIFE that occurred temporally related to the use of erenumab for migraine prevention.

Given the prevalence of migraines, knowledge of this unusual, rare dermatologic syndrome is important.

It is crucial to recognize the connection between the medication and the localized rash that may occur far from the injection site.

Carl H. Göbel, Axel Heinze, Sarah Karstedt, Anna Cirkel, Thomas F. Münte & Hartmut Göbel: First Report of Symmetrical Drug-related Intertriginous and Flexural Exanthema (SDRIFE or Baboon Syndrome) After Erenumab Application for Migraine Prevention. Pain Ther (2022).

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